Source Naturals, SAMe 200mg (SAM-e) Enteric Coated, 60 Tablets

SAMe - S-Adenosyl-L-Methionine 200 mg and 400 mg
Supports Joint Comfort, Function and Mobility

SAMe (SAM-e) is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. Studies also show that SAMe helps support a positive outlook. It is able to cross the blood-brain barrier where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAMe is known as a "methyl donor." This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. Methylation plays a part in many critical cellular functions. SAMe is present in every living cell in the body. However, levels of SAMe tend to decline with age.

SAMe - A Multipurpose Nutrient
SAMe, or S-adenosyl L-methionine, is formed when our bodies combine the amino acid L-methionine with ATP, the primary energy-carrying molecule in our cells. SAMe is a multipurpose nutrient, which is present in every living cell.

Because SAMe is involved in so many vital processes, it is important that our bodies produce sufficient SAMe. However, SAMe levels tend to decline with age, and also can be affected by dietary imbalances. To produce adequate amounts, we need to consume not only methionine-containing protein foods, but also foods rich in vitamins B-6, B-12 and folic acid, which are needed to ensure the synthesis of SAMe.

SAMe also is a highly unstable molecule. A lot of scientific research was needed to make it available as a supplement. Source Naturals has studied the research and offers this vital nutrient in a form your body can use.

Methylation is the Key
SAMe is known as a "methyl donor". This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. This methylation process affects the synthesis, activation and metabolism of various hormones, neurotransmitters, phospholipids, nucleic acids, proteins and other biological molecules. Methylation plays a part in many critical functions, including the maintenance of cell membranes, the removal of toxic substances from the body and the production of mood-boosting neurotransmitters such as dopamine and serotonin.

SAMe - Effective Joint Support
SAMe has been used in Europe for two decades for joint support. Dozens of clinical studies have demonstrated that SAMe supports joint comfort, function and mobility in the spine, hips and knees. SAMe is important in a process called transsulfuration. The breakdown of SAMe generates sulfate groups that help maintain joint cartilage. SAMe helps to form proteoglycans, which are used to renew the matrix of cartilage.

SAMe Promotes Mental Well-Being
Studies also show that SAMe helps support a positive outlook. Although the mechanism by which SAMe promotes mental well-being is not known, we do know it is able to cross the blood-brain barrier, where it affects the production of mood-boosting neurotransmitters.

Supplement Facts for 200 mg
Serving Size: 2 tablets
Amount %DV
SAMe (S-adenosyl-L-methionine) 400 mg
from 800 mg of SAMe disulfate tosylate

Other Ingredients: cellulose, mannitol, hydroxypropyl methylcellulose pthalate, citric acid, sodium starch glycolate, glyceryl triacetate, modified cellulose gum, stearic acid, colloidal silicon dioxide, titanium dioxide and yellow ochre.

Warning: If you are pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using SAMe product. Take this product under medical supervision if you have bipolar disorder. In a small percentage of people SAMe product may cause nausea which tends to subside with long-term use.

Suggested Use: Two SAMe tablets, one to three times daily. Take SAMe tablets on an empty stomach.

Source Naturals SAMe is suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no preservatives or artificial color, flavor or fragrance.