Source Naturals, SAMe 400mg (SAM-e) Enteric Coated, 30 Tablets

SAM-e - S-Adenosyl-L-Methionine 200 mg and 400 mg
Supports Joint Comfort, Function and Mobility

SAM-e (SAMe) is a stable, bioavailable form of S-adenosyl-L-methionine. These tablets are enteric coated and blister packed to prevent breakdown and inactivation of the ingredients. Dozens of clinical studies have demonstrated that SAM-e supports joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage formation. Studies also show that SAM-e helps support a positive outlook. It is able to cross the blood-brain barrier where it affects the synthesis and activation of various proteins, such as neurotransmitters. SAM-e is known as a "methyl donor." This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. Methylation plays a part in many critical cellular functions. SAM-e is present in every living cell in the body. However, levels of SAM-e tend to decline with age.

SAM-e - A Multipurpose Nutrient
SAM-e, or S-adenosyl L-methionine, is formed when our bodies combine the amino acid L-methionine with ATP, the primary energy-carrying molecule in our cells. SAM-e is a multipurpose nutrient, which is present in every living cell.

Because SAM-e is involved in so many vital processes, it is important that our bodies produce sufficient SAM-e. However, SAM-e levels tend to decline with age, and also can be affected by dietary imbalances. To produce adequate amounts, we need to consume not only methionine-containing protein foods, but also foods rich in vitamins B-6, B-12 and folic acid, which are needed to ensure the synthesis of SAM-e.

SAM-e also is a highly unstable molecule. A lot of scientific research was needed to make it available as a supplement. Source Naturals has studied the research and offers this vital nutrient in a form your body can use.

Methylation is the Key
SAM-e is known as a "methyl donor". This means that it works by giving up a piece of itself (a methyl group consisting of one carbon and three hydrogen atoms) to other molecules. This methylation process affects the synthesis, activation and metabolism of various hormones, neurotransmitters, phospholipids, nucleic acids, proteins and other biological molecules. Methylation plays a part in many critical functions, including the maintenance of cell membranes, the removal of toxic substances from the body and the production of mood-boosting neurotransmitters such as dopamine and serotonin.

SAM-e - Effective Joint Support
SAM-e has been used in Europe for two decades for joint support. Dozens of clinical studies have demonstrated that SAM-e supports joint comfort, function and mobility in the spine, hips and knees. SAM-e is important in a process called transsulfuration. The breakdown of SAM-e generates sulfate groups that help maintain joint cartilage. SAM-e helps to form proteoglycans, which are used to renew the matrix of cartilage.

SAM-e Promotes Mental Well-Being
Studies also show that SAM-e helps support a positive outlook. Although the mechanism by which SAM-e promotes mental well-being is not known, we do know it is able to cross the blood-brain barrier, where it affects the production of mood-boosting neurotransmitters.

Supplement Facts for 400 mg
Serving Size: 1 tablet
Amount %DV
SAM-e (S-adenosyl-L-methionine) 400 mg
from 800 mg of SAM-e disulfate tosylate

Other Ingredients: cellulose, hydroxypropyl methylcellulose phthalate, titanium dioxide, mannitol, stearic acid, triacetin, sodium starch glycolate, modified cellulose gum, citric acid, silica, and yellow ochre.

Warning: If you are pregnant, breastfeeding or are taking antidepressant medication, consult your physician before using SAM-e product. Take this product under medical supervision if you have bipolar disorder. In a small percentage of people SAM-e may cause nausea which tends to subside with long-term use.

Suggested Use: One SAM-e tablet, one to three times daily. Take SAM-e tablets on an empty stomach.

Source Naturals SAM-e is suitable for vegetarians. Contains no yeast, dairy, egg, gluten, soy or wheat. Contains no preservatives or artificial color, flavor or fragrance.